Job Function
If you think you are the right match for the following opportunity, apply after reading the complete description.
Discovery & Pre-Clinical/Clinical Development
Job Sub Function
Chemical Research
Job Category
Scientific/Technology
Job Posting Locations
Beerse, Antwerp, Belgium; Toledo, Spain
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science‑based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Purpose
Discovery Chemistry is an integral and growing part of the Innovative Medicine Therapeutic Discovery (TD) organization, which is committed to the delivery of high‑quality drug candidates in partnership with all six Therapeutic Area (TA) discovery organizations. The Discovery Product Development and Supply (DPDS) mission requires deep scientific expertise in multiple fields including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external organizations, including the discovery facing development teams
Discovery Product Research (DPR)
and
Developability .
We are seeking an outstanding, highly skilled, and motivated chemist with excellent organic synthesis and chemical biology expertise to lead and manage our internal chemical biology efforts toward delivering high quality hits, leads, and candidates to Johnson & Johnson’s discovery pipeline within our Disease and Pathway Area Stronghold (DAS) and PAS strategy.
The successful individual will be responsible for developing chemical probes and tool compounds to enable biological and mechanistic characterization of novel hits/hit series emerging from high-throughput screens and progressing them through stage-gates. They will be part of our Chemical Biology matrix team and will collaborate heavily with Chemoproteomics and High-Throughput Screening partners to deliver robust chemical biology data packages to discovery programs across Therapeutic Areas.
You Will Be Responsible For
Driving and directing chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions.
Independently designing and synthesizing chemical biology tools—including photoaffinity and photocatalytic proximity labeling probes—toward various applications, as well as supervising and directing synthetic chemistry activities at contract research organizations (CROs).
Forging a robust relationship with Discovery Technologies & Molecular Pharmacology (DTMP) Chemoproteomics team to design, propose, and implement chem bio strategies and workstreams to best align with Therapeutics Discovery overall goals.
Generating novel, testable hypotheses to enable clear decision making.
Presenting data and reports on project status at individual, group, and departmental meetings.
Maintaining a significant level of productivity in the laboratory setting.
Maintaining a healthy publication record in scientific journals and present findings at key conferences.
Education
A PhD in Organic Chemistry, Medicinal Chemistry, or Chemical Biology is required.
Experience and Skills
5+ years of post-PhD experience in Chemical Biology is required.
Experience in Structure-Activity Relationship (SAR)-driven design and synthesis of small molecules, with proven track record of delivering on high quality chemical biology probes and tool compounds with various applications is required.
Solid understanding of chemical biology and chemoproteomics methods is required, including activity-based protein profiling (ABPP), photoaffinity labeling, affinity chromatography, and cellular thermal shift assay (CETSA).
Demonstrated application of chemical biology toward addressing any of the following is required: target identification from phenotypic screens, target engagement in cells or lysate, covalent inhibitor selectivity profiling, binding site identification, and small-molecule mechanism of action (MOA) elucidation.
Strong track record of scientific contributions including peer-reviewed first-author publications and presentations at major conferences is required.
Being abreast of the latest advances in synthetic chemistry and chemical biology is required.
Ability to succeed within a matrix environment is required.
Preferred
Biopharmaceutical industry experience is preferred. xqknzec
Working understanding of targeted protein degradation strategies is desirable.
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