Senior Process Engineer
3 days ago Be among the first 25 applicants
Are you eager to lead innovation in stem cell manufacturing? Are you experienced with stem cells, and scalable bioreactor based manufacturing processes? As a Senior Process Engineer at Cellistic, you’ll play a key role in developing and optimizing GMP-compliant processes for cutting-edge stem cell therapies.
Cellistic is growing, and we’re looking for passionate team members who believe in the power of engineered cells as medicines, challenge the status quo, and thrive on bringing novel ideas to life.
The position
As a Senior Process Engineer, you will drive the development of a novel allogeneic chimeric antigen receptor T (CAR T) cell manufacturing process. The Senior Process Engineer will serve as the process subject matter expert, lead development, and coordinate the integration of multiple unit operations. In this role you will focus on the scale-up (and automation) of bio-processes for manufacturing products from pluripotent stem cells to CAR-T cells. The candidate will lead a multidisciplinary project team to execute the development plan, and support the technology transfer to GMP manufacturing team. This role will collaborate closely with multiple cross-functional teams including Analytical Development, Research, Supply Chain.
As a major part of the job responsibility includes hands-on processes development, the preferred candidate is a highly motivated researcher with desire to work in a laboratory-focused role.
Responsibilities:
* Develop pioneer processes and introduce state-of-the-art technologies to manufacture iPSC-derived T-cells therapeutics.
* Evaluate and implement technology to enhance consistency, scalability and cGMP compliance of bio-processes for manufacturing iPSC-derived T-cell therapeutics.
* Leverage high throughput experimental designs and equipment (from deep well plates to small scale bioreactors) to optimize cellular differentiation and optimize for product quality
* Develop scale-down models for process optimization studies.
* Evaluate and implement process analytic technologies (PAT) for improved monitoring and control of stem cell bio-processes.
* Responsible to plan technical work packages and deliver them according to quality and delivery targets, in alignment with the project manager.
* Write protocols, technical reports, and Standard Operating Procedures (SOPs).
* Participate in technology transfer of processes and equipment to the Manufacturing group.
* Collaborate with project teams to integrate processes.
* Ability to manage various priorities in a fast-paced and growing environment
* Document, share, present and communicate study results at meetings and in other formats
Qualifications:
* Ph.D. and 10+ years or MS and 15+ years of experience in bioengineering, chemical engineering, biology, biochemistry or related field
* Must have industry and project management experience; direct, hands-on industrial upstream experience (ideally in gene and/or cell therapy process development),
* Strong industrial upstream processing knowledge required from a small-scale cell culture process development perspective
* Industrial experience with biologics, gene and/or cell therapy upstream process development including ownership of key process decisions. Prior experience with different modes of cultivation such as fed batch and perfusion (ATF, TFF) desired
* Prior experience with primary cells, T or NK cell culture, stem cells (including hematopoietic stem cells), and /or stem cell differentiation desired
* Strong organizational, troubleshooting and interpersonal skills along with excellent oral and written communication
* Demonstrated ability to work in a fast-paced, collaborative, and matrixed organization environment.
* Ability to work a flexible schedule as weekend work is required
* Since we are working in an international environment, proficiency in English, both written and spoken, is a prerequisite.
As a person, you are open-minded and a good communicator by nature. You have a high level of energy that drives you and inspires your colleagues. You thrive in a changing and dynamic work environment, and in a job that requires you to be flexible, take initiatives and think out of the box when challenges occur. You are a true team-player who enjoys working in close collaboration with colleagues in and out of the laboratory.
Application Process:
Interested candidates should submit their resume and cover letter outlining qualifications and experience to careers@cellistic.com.
Cellistic is an equal opportunity employer committed to creating an inclusive environment for all employees.
Seniority level
* Seniority level
Mid-Senior level
Employment type
* Employment type
Full-time
Job function
* Job function
Engineering and Research
Referrals increase your chances of interviewing at Cellistic by 2x
Get notified about new Process Engineer jobs in Mont-Saint-Guibert, Walloon Region, Belgium.
Brabant, Walloon Region, Belgium 3 weeks ago
Brussels, Brussels Region, Belgium 1 week ago
Leuven, Flemish Region, Belgium 3 weeks ago
WATER TREATMENT UTILITIES PROCESS ENGINEER
Brussels, Brussels Region, Belgium 5 days ago
Seneffe, Walloon Region, Belgium 4 days ago
Aramco Global Opportunities Await - Relocation to Saudi Arabia
Brussels, Brussels Region, Belgium 1 week ago
Aramco Global Opportunities Await - Relocation to Saudi Arabia
Brabant, Walloon Region, Belgium 16 hours ago
Process Engineering Consultant - Visual Inspection
Grimbergen, Flemish Region, Belgium 2 months ago
Kortenberg, Flemish Region, Belgium 5 days ago
Leuven, Flemish Region, Belgium 1 month ago
Brussels, Brussels Region, Belgium 1 year ago
Junior Industrial Project Engineer (VIE) (Chemical / Process Engineering)
Braine-l’Alleud, Walloon Region, Belgium 1 year ago
Grimbergen, Flemish Region, Belgium 2 months ago
Brussels, Brussels Region, Belgium 14 hours ago
Tienen, Flemish Region, Belgium 1 month ago
Jemeppe, Walloon Region, Belgium 1 month ago
Brussels, Brussels Region, Belgium 12 hours ago
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr