Overview Associate Director or Principal Statistician, Real-World Biostatistics (RWB). Real-World Biostatistics (RWB) is a global role responsible for driving strategic initiatives for value delivery. These roles apply advanced biostatistical methods and AI tools to real world data (RWD) to generate real world evidence (RWE) for informing trial design, regulatory submissions, reimbursement and safety signals. The role works in close partnership with cross-functional teams across GSK and leads the development and optimization of RWE strategies for priority assets, ensuring data-driven decision-making generates the best evidence package for approvals. Site Names : USA - Pennsylvania - Philadelphia, Belgium - Wavre, Home Worker - GBR Posted Date : Oct 7 2025 Key Responsibilities Biostatistics: Lead the design and analysis of non-interventional studies, aligning with cross-functional teams, managing timelines, and ensuring methodological rigor and quality control. Apply statistical and RWD expertise to guide the selection and appropriate use of complex health data sets, co-develop variable definitions, code lists, and author technical specification documents. Develop and refine statistical analysis plans, conduct complex statistical analyses (e.g., causal inference, comparative effectiveness, target trial emulation), and communicate findings to internal and external stakeholders. Strategic Initiatives: Serve as a senior-level RWB consultant within matrix teams, leveraging in-depth expertise on assigned assets. Participate in enterprise-level strategic initiatives, such as Disease Area Acceleration Teams, for organizational deliverables. Communication: Present statistical analyses and insights to internal stakeholders and external audiences, including conferences and publications, demonstrating the value of biostatistical contributions. Engage in strategic communication to reinforce the role of biostatistics in driving innovation and decision-making. Methodological Development and Innovation: Stay informed on emerging industry trends and incorporate cutting-edge biostatistical methods to improve study designs and analytics. Conduct methodological research and contribute to development/application of new analytical techniques. Regulatory Support and Compliance: Provide biostatistical expertise on RWD during regulatory submissions, preparing for meetings and addressing regulatory queries to ensure compliance with industry standards. Stay current with regulatory guidance on the use of RWD for decision-making and advise on statistical approaches aligned with regulatory expectations. Why You? Basic Qualifications Ph.D. in Statistics, Data Science, Epidemiology, or related field with 6+ years of experience (or Master’s degree with 8+ years) for Associate Director; for Principal Statistician: PhD with 4+ years or Master’s with 3+ years in pharmaceutical/biotech, preferably in real-world evidence, epidemiology, or health outcomes research. Experience working with drug development processes utilizing statistical skills to achieve project and business objectives. Experience using RWD (e.g., electronic health records, insurance claims, registries) and applying observational study designs and biostatistical principles in clinical/epidemiological research. Proficiency in programming languages R and SQL, with applied experience working with observational datasets. Experience contributing to methodological research and publications in biostatistics and real-world data analytics. Preferred Qualifications Experience working within regulatory frameworks related to RWD. Experience in advanced biostatistical techniques including causal inference, comparative effectiveness, time-to-event analysis, longitudinal and predictive modelling, and external control arms. Familiarity with machine learning techniques and applications in real-world data analysis. Ability to manage complex projects and deliver high-quality results in dynamic environments. Strong communication and interpersonal skills to convey complex statistical concepts. Fluency in written and spoken English. Why Join Us? At GSK, we are united by a shared purpose: helping people do more, feel better, and live longer. As Associate Director/Principal Statistician of Real-World Biostatistics, you will contribute to advancing pharmaceutical science and developing life-changing medicines. GSK offers opportunities to work on cutting-edge projects, collaborate with talented teams, and drive innovation in healthcare. Salary and benefits: The US annual base salary for new hires ranges from $108,750 to $181,250, with bonuses and eligibility for long-term incentive programs. Available benefits include health care and other insurance, retirement benefits, paid holidays, vacation, and parental/maternity and sick leave. Salary details by country will be discussed during recruitment if not displayed. Please visit GSK US Benefits Summary to learn more about the benefits program. Why GSK? GSK is a global biopharma company committed to uniting science, technology and talent to get ahead of disease together. We focus on four therapeutic areas and strive to impact health at scale. If you require accommodation to apply, contact GSK Service Centre. Compliance GSK is an Equal Opportunity Employer. This ensures all qualified applicants receive equal consideration for employment without regard to race, color, religion, sex, pregnancy, gender identity, sexual orientation, parental status, national origin, age, disability, genetic information, military service or any basis prohibited by law. Important notice to Employment businesses/Agencies GSK does not accept referrals from employment businesses or agencies unless prior written authorization is obtained. This is a condition precedent to any agreement. GSK shall not be liable for fees arising from such referrals. For US, CMS Open Payments information is available via CMS.gov. #J-18808-Ljbffr