Role: Clinical Pharmacology Lead
Location: Hybrid - must be able to commit to 2x days per week in Antwerp
The Role
We are seeking a highly Senior Clinical Pharmacology Lead to play a key, senior role in advancing a growing portfolio of innovative small-molecule therapies. This is a hands-on position with significant scientific ownership, where you will lead clinical pharmacology strategy from early translational development through proof of concept and beyond. You will act as a core individual contributor while progressively taking on broader leadership responsibilities as the pipeline and organization expand.
The Company
You will join a fast-growing, science-driven biotechnology company focused on developing novel therapies for serious diseases with high unmet medical need. The company combines deep biological insight with a strong commitment to translational science, quantitative decision-making, and close cross-functional collaboration. With an agile culture and ambitious development goals, this environment offers the opportunity to make a visible impact on programs and patients alike.
Key Responsibilities
* Serve as the Clinical Pharmacology lead for assigned clinical programs
* Develop and execute integrated clinical pharmacology plans aligned with overall clinical development strategy
* Design and support clinical pharmacology and PK/PD study protocols
* Perform and/or oversee population PK/PD, PBPK, and other quantitative analyses
* Apply model-informed drug development to support dose selection and compound progression
* Integrate nonclinical, translational, biomarker, and clinical data into coherent modelling strategies
* Interpret emerging PK/PD and biomarker data to inform development decisions
* Contribute to regulatory documents including INDs, IBs, protocols, and briefing packages
* Support regulatory interactions by providing data-driven dose and development justifications
* Collaborate closely with research, toxicology, clinical operations, biometrics, regulatory, and medical teams
* Manage and scientifically oversee CROs and external consultants
* Help build and mentor future clinical pharmacology team members as the function grows
Requirements
* PhD, PharmD, MD, or equivalent degree in pharmacology, pharmaceutical sciences, or a related field
* 10+ years of experience in clinical pharmacology within biotech or pharmaceutical development
* Strong expertise in PK/PD, population modelling, PBPK, dose optimization, and quantitative pharmacology
* Hands-on experience supporting small-molecule drug development programs, including novel therapeutic approaches
* Ability to operate effectively as both an individual contributor and an emerging people leader
* Strong communication, organizational, and cross-functional collaboration skills
* Comfortable working in a fast-paced, growth-stage biotech environment
* Fluency in English; additional languages are a plus