JobTitle : Chief Operating Officer (COO) Status: Full Time Location: Primarily on-site – Liège laboratory, Belgium Salary: Competitive Reporting to: CEO Company Today, precision medicine coupled with advanced diagnostics is taking over. However, those innovations in medicine come with an ever‑increasing price tag driven by more expensive and complicated solutions making them less accessible unless we do something about it. SignaturBiosciences was established with the mission of making cutting‑edge diagnostic tools accessible to more patients around the world. As a startup we have developed a technology to profile complex molecular signatures in a single reaction using qPCR machines already in place in every biomedical lab around the world. SignaturBiosciences is a startup based in Liege, Belgium, and London, UK. We’re worried about accessibility in precision diagnostics and are building a team of individuals who share our passion for solving this problem through close collaboration and a sense of urgency. We’re building a different kind of company; we value speed, ownership, and execution over bureaucracy; employees think like owners and collaborate closely with one another. We are seeking a highly motivated and driven COO to join our team. In this role, reporting to the CEO, you will be responsible for operationalising the strategy and ensuring the company runs efficiently, predictably, and at speed as we transition from development to commercial‑stage operations. You will work closely with the entire team, including quality, regulatory, R&D, HR, laboratory operations and finance and further build on these existing competencies to develop a fully integrated manufacturing capability. If you are a hands‑on, execution‑driven operator with deep experience in regulated IVD environments, a strong sense of ownership, and a bias for action, we’d love to speak with you. About the role As COO, you will take full ownership of operations, manufacturing execution, and quality system implementation at the Liège site, ensuring that SignaturBiosciences scales efficiently while remaining compliant with ISO 13485 and IVDR requirements. You will be accountable for the on‑site team in Liège (currently ~6 people and expanding), providing senior leadership to translate company strategy into concrete execution and ensuring a high‑performing and motivated team as part of an international organization. As COO, you will be an integral part of the executive team, working closely with the CEO, to help shape and develop the organization to ensure the successful execution of the company's strategy. This is not a corporate or purely strategic role — it is a hands‑on leadership position, embedded in the lab and close to the work. Success in this role means that teams are empowered, decisions are taken at the right level, and the company operates with clarity, speed, and confidence. Main Responsibilities End‑to‑end operational execution across manufacturing, quality, and internal processes Ownership of manufacturing operations, including day‑to‑day execution, scale‑up readiness, commercial distribution and alignment with quality and regulatory requirements Operational interfaces with suppliers, partners, and external vendors, including supplier agreements, cost control, and active management of COGS Ensuring successful interface with development to enable efficient