Senior QC Supervisor – CAR T Manufacturing
Are you passionate about playing a key role in the production of life-saving cell therapies? Join us as a Senior QC Supervisor in CAR T Manufacturing, you will play a pivotal role in the production of life-saving, personalized cell therapies. You'll be part of a dynamic team in a state-of-the-art GMP facility where innovation meets impact, and your leadership directly contributes to delivering hope to patients worldwide.
This is more than a job — it's a purpose. You'll be leading a team that ensures rigorous in-process quality control (IPL), environmental monitoring, and seamless sample handling in support of both clinical trials and commercial manufacturing. Your expertise will uphold the highest standards of compliance, excellence, and efficiency in a rapidly growing biotech environment.
This position requires shift work.
What can you expect?
* A high-impact leadership role in a cutting-edge CAR T cell therapy facility
* An opportunity to shape and develop a growing QC team
* Cross-functional collaboration across manufacturing, quality, and technical operations
* Involvement in strategic planning and continuous improvement initiatives
* A chance to contribute to life-changing therapies and be part of a patient-focused mission
* A workplace culture rooted in collaboration, quality, and accountability
Here's what you'll do:
Daily Operations
* Oversee QC operations related to in-process testing and environmental monitoring (EM)
* Create and coordinate shift schedules with QC schedulers and supervisors
* Act as GMP decision-maker and liaise with QA and operational teams
* Manage and escalate issues impacting product release timelines
* Initiate and support non-conformance investigations and CAPA activities
* Assist in capacity planning and budget forecasting
* Contribute to organizational strategy and team optimization
People & Cross functional collaboration
* Lead daily meetings and foster a culture of engagement and accountability
* Recruit, coach, and develop QC analysts and QC support technicians
* Build strong cross-functional relationships across Quality, IT, Maintenance, Manufacturing, and others.
* Act as back-up for the (Senior) QC Manager as needed
Operational Excellence & Projects
* Drive data collection and performance analysis for IPL, EM, and sample transport
* Define and track key performance indicators (KPIs)
* Lead and implement improvement projects from concept to completion
* Support cross-functional initiatives via change management processes
Quality & Compliance
* Act as QC SME in reviews and audits; prepare for inspections
* Support risk assessments and ensure training compliance
* Stay current with evolving regulations and best practices
* Uphold GMP and regulatory standards at all times
Who are we looking for?
A proactive, detail-oriented leader with a deep understanding of GMP and QC operations in a cell therapy or biopharmaceutical environment. You have a passion for people development, operational excellence, and scientific integrity. You thrive in fast-paced, high-stakes environments and are confident in making data-driven decisions while leading a team with empathy and precision.
Education:
* Bachelor’s degree (or higher) in Science, Engineering, or a related technical discipline
* Equivalent experience in the biotech/pharmaceutical industry will be considered
Experience:
* Minimum 7 years of relevant work experience in a GMP or ATMP lab environment
* At least 4 years in Quality Control, with preference for aseptic manufacturing experience
* 5+ years in leadership roles, with experience in team development and performance management
Languages:
* Fluent in Dutch and English, both written and spoken
Strengths:
* Strong communicator and team builder
* Resilient and adaptable under shifting priorities
* Highly organized with excellent attention to detail
* Critical thinker with a solution-driven mindset
* Capable of influencing cross-functional teams and stakeholders
Expertise:
* Knowledge of GMP, GTP, and cell therapy manufacturing
* Familiarity with FDA/EU regulations including 21 CFR Parts 210, 211, 1271, and preferably 600–610
* Skilled in root cause analysis, CAPA, and risk management
* Experience leading audits and functioning as an SME during inspections
* Proficiency in Microsoft Office (Word, Excel, PowerPoint, Outlook)
* Experienced in resource planning, scheduling, and budget preparation
* Comfortable with shift work, including weekends and unplanned overtime
What do we offer you?
* A meaningful job with an excellent work-life balance. You will work 4 days. After that you will enjoy 4 days off.
* A supportive and innovative work environment. We value and encourage learning and personal development.
* The opportunity to work with people from all over the world.
* A contract of indefinite duration and an attractive salary package complemented by many fringe benefits, such as additional statutory vacations, meal vouchers, group and hospitalization insurance, double vacation pay, an end-of-year and performance bonus.
* Many fun and informal events.
About Legend Biotech
Legend Biotech is a global biotechnology company dedicated to developing, manufacturing, and commercializing innovative and life-saving cell therapies for the treatment of chronic and life-threatening diseases, such as cancer.
The company was founded in 2014 and is headquartered in Somerset, New Jersey. Legend Biotech now employs over 2,400 people across six global manufacturing sites. Two of these sites are in Ghent: Obelisc (Technology Park Zwijnaarde) and Tech Lane (Eilandje Zwijnaarde).
In Ghent, Legend Biotech focuses on the production of advanced CAR-T cell therapies for the treatment of multiple myeloma, in close collaboration with Johnson & Johnson.
Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.
Legend Biotech maintains a drug-free workplace.