Principal Scientist pharmacokinetic/pharmacodynamic modeling expert
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At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com
Job Function
Discovery & Pre-Clinical/Clinical Development
Job Sub Function
Pharmacokinetics & Pharmacometrics
Job Category
Scientific/Technology
Location
Beerse, Antwerp, Belgium
Job Description
We are searching for a talented Principal Scientist pharmacokinetic/pharmacodynamic modeling expert in the Translation Pharmacokinetic Pharmacodynamic and Investigative Toxicity (TPPIT) group within Preclinical Safety and Translational Sciences (PSTS), located in Beerse, Belgium.
The successful candidate will be employed within our PBPK/PD modelling team in TPPIT.
Key Responsibilities
* Represent PSTS/TPPIT as pharmacokinetic/pharmacodynamic modelling expert in cross-functional project teams and external collaborations.
* Independently develop and apply PBPK/PD models to explore effects of target and pathway modulation, define candidate drug target profiles, and project human exposure profiles.
* Predict human dose and regimen, contribute to exposure and pharmacodynamic biomarker-based decision-making for early clinical trials.
* Interpret and communicate modelling results and their impact to project teams.
* Design, conduct, interpret, and prepare study and regulatory summaries of PBPK and PKPD M&S activities.
* Prepare PBPK and/PKPD M&S strategies to support discovery and development programs.
* Drive learning through back-translation of clinical exposure and pharmacodynamic data, offering strategic options for future clinical testing.
* Act as main contact for team members regarding study design and data analysis to support clinical candidate selection and medicine development.
* Guide junior colleagues through consultation and mentoring in techniques and processes, providing functional supervision.
We encourage a desire for learning and innovation, and ongoing career development through participation in scientific meetings, publications, external organizations, and presentations at major scientific, industry, and regulatory events.
Required Qualifications / Requirements
* PhD in pharmaceutical sciences, pharmacometrics, computational biology, chemical/biomedical engineering, or a related field.
* Hands-on experience with PBPK/PKPD analysis and modelling tools (e.g., Monolix, Matlab, Phoenix, GastroPlus, SimCYP).
* Broad understanding of DMPK areas like physicochemical properties, enzyme & transporter kinetics.
* Excellent communication skills in English, strong interpersonal skills, organizational ability, attention to detail, and ability to work collaboratively across US and EU teams.
* Active collaboration with industry, academia, and regulatory agencies.
Preferred Qualifications
* Minimum of 6 years industry experience supporting discovery/development projects.
* Experience with mechanistic frameworks like QSP.
* Skills in experimental design, data analysis, and integrating large datasets and literature.
Additional Details
* Seniority level: Not Applicable
* Employment type: Full-time
* Job function: Research, Analyst, and IT
* Industry: Pharmaceutical Manufacturing
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