Ph3Job Function /h3pDiscovery Pre-Clinical/Clinical Development /ph3Job Sub Function /h3pChemical Research /ph3Job Category /h3pScientific/Technology /ph3Job Posting Locations /h3pBeerse, Antwerp, Belgium; Toledo, Spain /ph3About Innovative Medicine /h3pOur expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science‑based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. /ppJoin us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. /ph3Purpose /h3pDiscovery Chemistry is an integral and growing part of the Innovative Medicine Therapeutic Discovery (TD) organization, which is committed to the delivery of high‑quality drug candidates in partnership with all six Therapeutic Area (TA) discovery organizations. The Discovery Product Development and Supply (DPDS) mission requires deep scientific expertise in multiple fields including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external organizations, including the discovery facing development teams bDiscovery Product Research (DPR) /b and bDevelopability /b. /ppWe are seeking an outstanding, highly skilled, and motivated chemist with excellent organic synthesis and chemical biology expertise to lead and manage our internal chemical biology efforts toward delivering high quality hits, leads, and candidates to Johnson Johnson’s discovery pipeline within our Disease and Pathway Area Stronghold (DAS) and PAS strategy. /ppThe successful individual will be responsible for developing chemical probes and tool compounds to enable biological and mechanistic characterization of novel hits/hit series emerging from high-throughput screens and progressing them through stage-gates. They will be part of our Chemical Biology matrix team and will collaborate heavily with Chemoproteomics and High-Throughput Screening partners to deliver robust chemical biology data packages to discovery programs across Therapeutic Areas. /ph3You Will Be Responsible For /h3ulliDriving and directing chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions. /liliIndependently designing and synthesizing chemical biology tools—including photoaffinity and photocatalytic proximity labeling probes—toward various applications, as well as supervising and directing synthetic chemistry activities at contract research organizations (CROs). /liliForging a robust relationship with Discovery Technologies Molecular Pharmacology (DTMP) Chemoproteomics team to design, propose, and implement chem bio strategies and workstreams to best align with Therapeutics Discovery overall goals. /liliGenerating novel, testable hypotheses to enable clear decision making. /liliPresenting data and reports on project status at individual, group, and departmental meetings. /liliMaintaining a significant level of productivity in the laboratory setting. /liliMaintaining a healthy publication record in scientific journals and present findings at key conferences. /li /ulh3Education /h3pA PhD in Organic Chemistry, Medicinal Chemistry, or Chemical Biology is required. /ph3Experience and Skills /h3ulli5+ years of post-PhD experience in Chemical Biology is required. /liliExperience in Structure-Activity Relationship (SAR)-driven design and synthesis of small molecules, with proven track record of delivering on high quality chemical biology probes and tool compounds with various applications is required. /liliSolid understanding of chemical biology and chemoproteomics methods is required, including activity-based protein profiling (ABPP), photoaffinity labeling, affinity chromatography, and cellular thermal shift assay (CETSA). /liliDemonstrated application of chemical biology toward addressing any of the following is required: target identification from phenotypic screens, target engagement in cells or lysate, covalent inhibitor selectivity profiling, binding site identification, and small-molecule mechanism of action (MOA) elucidation. /liliStrong track record of scientific contributions including peer-reviewed first-author publications and presentations at major conferences is required. /liliBeing abreast of the latest advances in synthetic chemistry and chemical biology is required. /liliAbility to succeed within a matrix environment is required. /li /ulh3Preferred /h3ulliBiopharmaceutical industry experience is preferred. /liliWorking understanding of targeted protein degradation strategies is desirable. /li /ul /p #J-18808-Ljbffr