Ph3Job Description /h3 pWe are seeking an exceptional Principal Scientist to help advance our neuroscience discovery efforts through high‑content imaging and disease‑relevant cellular models in neurodegeneration. The role involves building innovative assay and imaging approaches, generating impactful insights from complex model systems, and driving discovery programs forward in a highly connected research environment. /p h3Key Responsibilities /h3 ul liHands‑on assay development in neurodegeneration models. /li liDevelop, optimize, and execute assays in complex in vitro models, including primary models, aggregation models, and cell lines, to address diverse scientific questions while ensuring robustness, relevance, and scalability. /li liGenerate high‑quality, reproducible data in physiologically relevant laboratory models to enable compound profiling and deepen biological understanding. /li liInterpret complex datasets and translate findings into clear scientific recommendations for project teams and cross‑functional stakeholders. /li liDrive mechanistic insight by integrating assay outcomes from diverse cellular systems with broader pharmacology and translational data. /li liApply scientific expertise in neuroscience and neurodegeneration to select the most appropriate model systems and assay approaches based on research questions, program stage, and decision‑making needs. /li liDocument experimental work with rigor and communicate results clearly in team discussions, reports, and project updates. /li liOwn high‑content imaging workflows in cellular pharmacology, including experimental design, acquisition settings, quality control, troubleshooting, downstream analysis, and data interpretation. /li liLead hands‑on imaging efforts in complex and physiologically relevant models for neurodegeneration. /li liProvide technical expertise across imaging modalities, including high‑content imaging, live‑cell imaging, and confocal/spinning‑disk microscopy, and apply the most appropriate modality to the scientific question. /li liAnalyze high‑content imaging data in complex models (e.g., neuronal systems, co‑cultures, and 3D models), quantify relevant phenotypes, markers, and cellular states, and generate meaningful readouts that distinguish healthy versus disease or treated versus control conditions. /li liAct as a senior hands‑on scientist within neuroscience programs, bringing deep technical expertise, strong experimental judgment, and a high standard of scientific rigor. /li liLead by example through scientific excellence, rigorous execution, and generation of high‑quality, reproducible data. /li liTakes ownership of scientific questions and experimental approaches within their area of expertise, and contributes clear, data‑driven recommendations to project teams. /li liWorks collaboratively across functions and contributes as a trusted scientific partner to program progress and team success. /li liProvides mentorship and scientific guidance to junior scientists, helping build technical capability and scientific confidence across the team. /li /ul h3Required Qualifications /h3 ul liPh.D. in Biomedical Sciences, Neurosciences or equivalent industry experience. /li liAt least 5 years of industry experience in drug discovery or translational research. /li liDeep hands‑on experience in neurodegeneration‑relevant cellular models, including neuronal aggregation models and other disease‑relevant in vitro systems used for mechanistic studies, phenotypic profiling, and translational decision‑making. /li liProven hands‑on expertise in high‑content imaging, including assay development, image acquisition, data analysis, and interpretation in complex cellular systems within a cell biology or drug discovery setting. /li liAbility to define and implement quality metrics for assay robustness and reliable image‑based readouts. /li liProven ability to independently plan work, troubleshoot, keep meticulous records, and communicate results to cross‑functional partners. /li /ul h3Preferred /h3 ul liExperience programming in R or Python for high‑content imaging data analysis. /li /ul h3Key Competencies /h3 ul liStrong bench‑based scientific judgment in neuroscience and neurodegeneration research. /li liScientific rigor, attention to detail, and meticulous record‑keeping. /li liCollaborative mindset and ability to work effectively with cross‑functional stakeholders across multiple projects and priorities. /li liPractical problem‑solving skills, including the ability to translate complex datasets from translational models into clear, decision‑relevant scientific recommendations. /li /ul h3Preferred Skills /h3 ul liBig Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability /li /ul h3Base Pay Range /h3 p€79,800.00 – €137,770.00 /p h3Benefits /h3 pIn addition to base pay, we offer the following benefits: an annual bonus with target pay‑grade based percentages, vacation days, parental leave, bereavement leave, caregiver leave, volunteer leave, well‑being reimbursement, programs for financial, physical, and mental health, service anniversary and recognition awards, and eligible insurance plans for employees and some dependents. Amounts and actual benefits may vary by location and are subject to change. /p h3Inclusive Work Environment /h3 pWe provide an inclusive work environment where each employee is considered as an individual. We respect diversity and dignity, recognize merit, and strive to create a respectful workplace for everyone. /p /p #J-18808-Ljbffr