Ph3Job Function /h3pDiscovery Pre-Clinical/Clinical Development /ph3Job Sub Function /h3pBiological Research /ph3Job Category /h3pScientific/Technology /ph3Job Location /h3pBeerse, Antwerp, Belgium /ph3Job Description /h3pWe are seeking an exceptional Principal Scientist to advance our neuroscience discovery efforts through high‑content imaging and disease‑relevant cellular models in neurodegeneration. The role involves developing assays, generating insights, and guiding discovery programs toward future therapies for patients with unmet needs. /ph3Key Responsibilities /h3ollipHands‑on assay development in neurodegeneration models: /pulliDevelop, optimize, and execute assays in complex in‑vitro models (primary, aggregation, cell lines). /liliGenerate high‑quality, reproducible data in physiologically relevant models for compound profiling and biological understanding. /liliInterpret complex datasets and translate findings into clear scientific recommendations for project teams and cross‑functional stakeholders. /liliIntegrate assay outcomes with broader pharmacology and translational data to drive mechanistic insight. /liliDocument experimental work rigorously and communicate results in reports and project updates. /li /ul /lilipHigh‑content imaging and analysis in neurodegeneration models: /pulliOwn complete imaging workflows including experimental design, acquisition settings, quality control, troubleshooting, downstream analysis, and data interpretation. /liliLead hands‑on imaging efforts in complex, physiologically relevant models for neurodegeneration. /liliProvide technical expertise across imaging modalities (high‑content imaging, live‑cell imaging, confocal/spinning‑disk microscopy). /liliAnalyze high‑content imaging data in complex models (neuronal systems, co‑cultures, 3D models) to quantify relevant phenotypes and generate meaningful readouts. /li /ul /lilipLeadership expectations: /pulliAct as a senior hands‑on scientist within neuroscience programs, demonstrating deep technical expertise and rigorous execution. /liliTake ownership of scientific questions and experimental approaches, offering data‑driven recommendations. /liliCollaborate across functions, serving as a trusted scientific partner to program progress. /liliMentor junior scientists, building technical capability and scientific confidence across the team. /li /ul /li /olh3Required Qualifications /h3ulliPh.D. in Biomedical Sciences, Neurosciences or equivalent, with at least 5 years of industry experience in drug discovery or translational research. /liliDeep hands‑on experience in neurodegeneration‑relevant cellular models (neuronal aggregation models and disease‑relevant in‑vitro systems). /liliProven expertise in high‑content imaging, including assay development, image acquisition, data analysis, and interpretation in complex cellular systems. /liliAbility to define and implement quality metrics for assay robustness and image‑based readouts. /liliIndependent planning, troubleshooting, meticulous record‑keeping, and effective communication of results to cross‑functional partners. /li /ulh3Preferred Experience /h3ulliProgramming in R or Python for high‑content imaging data analysis. /li /ulh3Key Competencies /h3ulliStrong bench‑based scientific judgment in neuroscience and neurodegeneration research. /liliScientific rigor, attention to detail, and meticulous record‑keeping. /liliCollaborative mindset and effective cross‑functional stakeholder engagement. /liliPractical problem‑solving skills, translating complex datasets into decision‑relevant scientific recommendations. /li /ulh3Required Skills /h3ulliBig Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability /li /ulh3Preferred Skills /h3ulliBig Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability /li /ulh3Salary /h3pBase pay range: €79,800.00 – €137,770.00 /ph3Benefits /h3ulliAnnual bonus with set target (percentage of pay) based on employee and company performance, or sales commissions. /liliVacation days, parental leave (minimum 12 weeks), bereavement leave, caregiver leave, volunteer leave, well‑being reimbursement. /liliPrograms for financial, physical, and mental health. /liliService anniversary and recognition awards. /liliParticipation in several insurance plans (subject to terms of respective plans and eligibility). /li /ul /p #J-18808-Ljbffr