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Principal scientist, analytical chemistry

Geel
7555-Janssen Pharmaceutica NV Legal Entity
Publiée le 7 juin
Description de l'offre

Ph3Principal Scientist, Analytical Chemistry (High‑Resolution Mass Spectrometry) /h3pLocation: Beerse, Antwerp, Belgium /ppJob Function: Discovery Pre-Clinical/Clinical DevelopmentbrJob Sub Function: Pharmaceutical Product RDbrJob Category: Scientific/Technology /ph3Key Responsibilities /h3ulliDevelop, optimize, and apply LC‑HRMS methods for fit‑for‑purpose characterization of reaction mixtures, intermediates, APIs, and related impurities across small molecules and peptides. /liliApply HRMS‑based characterization to resolve analytical questions during process development, including molecular formula assignment, interpretation of accurate‑mass and fragmentation data, impurity/byproduct identification, and troubleshooting of process‑related observations. /liliIntegrate HRMS data with chromatographic and complementary analytical readouts to convert complex datasets into clear, actionable process understanding that supports fit‑for‑purpose development decisions. /liliProvide cross‑portfolio HRMS support wherever needed, partnering with chemists and analytical colleagues to address characterization needs across projects. /liliStrengthen digital ways of working by contributing to automated data processing, reproducible analytical workflows, and structured data practices that improve traceability, consistency, and data‑to‑insight efficiency. /liliApply complementary analytical techniques beyond HRMS (e.g., chromatography, spectroscopic or other fit‑for‑purpose tools) as needed to support investigations and project delivery. /liliMentor and coach colleagues in your expertise and contribute to building sustainable capabilities and knowledge‑sharing within the PAR team. /liliActively contribute to scientific publications, adopt new technologies, and build strong internal and external scientific networks. /li /ulh3Experience and Skills /h3ulliPhD in Analytical Chemistry, Organic Chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences, or related discipline with 5+ years relevant industrial experience; or MSc with 9+ years relevant experience. /liliDemonstrated depth in LC‑HRMS, including accurate‑mass measurement, isotope pattern interpretation, and fragmentation analysis applied to support high‑quality analytical decision‑making in small‑molecule and peptide process development. /liliExperience with HRMS‑based peptide characterization workflows for sequence confirmation, impurity assessment, comparability studies, and investigation of product‑related heterogeneity. /liliExperience applying LC‑HRMS for confirmation of expected products, impurity/byproduct profiling, degradation or reaction‑mixture analysis, and analytical troubleshooting in process development. /liliHands‑on experience with digital enablement such as Python‑based data processing, workflow automation, and development of reproducible analytical pipelines. /liliFamiliarity with LC/GC/SFC/IC and common LC modes (RP, HILIC; plus IEX/SEC/HIC as applicable). /liliKnowledge of organic chemistry and chemical process development is a plus. /liliStrong scientific communication skills (oral and written), fluent in English. /liliProven scientific track record (publications, patents, technical leadership). /li /ulh3Key Behaviours /h3ulliCooperative spirit within a diverse, multidisciplinary team. /liliEnthusiasm for laboratory work and fostering teamwork. /liliCritical thinking and creativity in addressing complex challenges. /liliProactive identification of improvement opportunities and receptiveness to new ideas. /liliFlexible adjustment of priorities and strategies to meet evolving project needs. /liliMentoring and role modeling within the team. /liliConstructive challenge of status quo and advocacy for innovative solutions. /liliInclusive environment encouraging diverse perspectives. /li /ulh3Compensation and Benefits /h3pBase pay range: €79,800.00–€137,770.00per year /ppBenefits include: annual bonus based on performance, vacation days, parental leave (minimum 12weeks), bereavement, caregiver and volunteer leave, well‑being reimbursement, financial, physical and mental health programs, service anniversary awards, and eligibility for multiple insurance plans in applicable locations. /p /p #J-18808-Ljbffr

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